Welcome Yussuf. There is no natural niche perfumery, all those who make natural botanical perfumes without ingredients from bio-technologies are small artisans.
Niche means branding, marketing and distributying. None of the recognized niche perfume houses can afford to make 100% natural botanical perfumes. They MUST use molecules from the bio technologies.

On this forum of natural perfumery, Niche perfumery is rather out of topics, but there is much to discuss about the single molecules from the bio technologies. Maybe in an other thread.